Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.74 |
| ▸ | PDE4A | P27815 | 1/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | XDH | P47989 | 1/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456573 | 1.00 | ABCG2 (0.76) | ABCG2MAPTTNFRSF1APDE4APDE4B | |
| SCHEMBL16616651 | 0.91 | ABCG2 (0.72) | ABCG2MAPTTNFRSF1APDE4APDE4B | |
| SCHEMBL16616648 | 0.91 | ABCG2 (0.72) | ABCG2MAPTTNFRSF1APDE4APDE4B | |
| SCHEMBL4449840 | 0.90 | MAPT (0.76) | ABCG2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL4449836 | 0.90 | MAPT (0.76) | ABCG2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL2462050 | 0.85 | MAPT (1.00) | ABCG2MAPTTNFRSF1APDE4APDE4B | |
| Metochalcone SCHEMBL309111 | 0.85 | ABCG2 (1.00) | ABCG2MAPTTNFRSF1APDE4APDE4B | |
| Metochalcone SCHEMBL4957703 | 0.85 | ABCG2 (1.00) | ABCG2MAPTTNFRSF1APDE4APDE4B | |
| SCHEMBL2462049 | 0.85 | MAPT (1.00) | ABCG2MAPTTNFRSF1APDE4APDE4B | |
| Metochalcone SCHEMBL29412184 | 0.85 | ABCG2 (1.00) | ABCG2MAPTTNFRSF1APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | claimed |
| EP-1976818-A2 | CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2008-10-08 | — | — | EP | claimed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | claimed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | disclosed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | disclosed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | disclosed |
| EP-1976818-A2 | CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | ABCE1, CCNE1, FOXM1 | ABCG2 38/4885MAPT 4453/4885TNFRSF1A 2869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.