SCHEMBL4456614

SCHEMBL4456614

CC(C)(C)OC(=O)N1CCC(S(=O)(=O)c2ncnc3c(-c4ccc(S(C)(=O)=O)cc4)noc23)CC1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.73
FAAH O00519 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL389479 0.85 GPR119 (0.73) GPR119FAAH
SCHEMBL386450 0.85 GPR119 (1.00) GPR119
SCHEMBL390465 0.80 GPR119 (0.67) GPR119
SCHEMBL4768567 0.76 GPR119 (0.68) GPR119
SCHEMBL389524 0.73 GPR119 (0.73) GPR119
SCHEMBL388346 0.73 GPR119 (1.00) GPR119
SCHEMBL905129 0.73 GPR119 (0.65) GPR119
SCHEMBL1243560 0.73 GPR119 (0.79) GPR119
SCHEMBL4414294 0.69 GPR119 (0.63) GPR119
SCHEMBL1244926 0.69 GPR119 (0.50) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1808168-B1 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level ARENA PHARM INC (US) 2009-06-03 EP disclosed