SCHEMBL1243560

SCHEMBL1243560

CS(=O)(=O)c1ccc(-c2noc3c(OC4CCN(C(=O)O)CC4)ncnc23)cc1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.79
PIK3CD O00329 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL386450 0.89 GPR119 (1.00) GPR119
SCHEMBL388346 0.89 GPR119 (1.00) GPR119
SCHEMBL5048689 0.84 GPR119 (0.66) GPR119PIK3CD
SCHEMBL27755048 0.75 GPR119 (0.58) GPR119PIK3CD
SCHEMBL389479 0.73 GPR119 (0.73) GPR119
SCHEMBL4456614 0.73 GPR119 (0.73) GPR119
SCHEMBL1244926 0.72 GPR119 (0.50) GPR119
SCHEMBL3285206 0.71 GPR119 (0.65) GPR119
SCHEMBL288589 0.71 GPR119 (0.80) GPR119
SCHEMBL3811610 0.70 GPR119 (0.49) GPR119PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2292620-A2 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto Arena Pharmaceuticals, Inc. (US) 2011-03-09 EP disclosed
EP-2287166-A2 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto Arena Pharmaceuticals, Inc. (US) 2011-02-23 EP disclosed
EP-2287165-A2 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto Arena Pharmaceuticals, Inc. (US) 2011-02-23 EP disclosed