Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.87 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.58 |
| ▸ | ADH1B | P00325 | 1/20 | 0.57 |
| ▸ | ADH1C | P00326 | 1/20 | 0.57 |
| ▸ | ADH1A | P07327 | 1/20 | 0.57 |
| ▸ | ADH4 | P08319 | 1/20 | 0.57 |
| ▸ | ADH7 | P40394 | 1/20 | 0.57 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6385119 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL29136407 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL29136406 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL28708092 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL128597 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL6395851 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL6390459 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL7093599 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL126229 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Bromide SCHEMBL27860834 | 1.00 | TSHR (0.87) | TSHRALDH1A1EPHX1ADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108816052-A | A kind of reverse osmosis research of non-phosphorus scale inhibitor and preparation method thereof | 杨飞 | 2018-11-16 | — | — | CN | claimed |
| US-20020016505-A1 | Heat storage material having solid/solid phase transition remains solid through application; heat resistance; materials handling | MERCK PATENT GMBH (DE) | 2002-02-07 | — | — | US | claimed |
| EP-1148108-A1 | Storage media for latent heat storage units | MERCK PATENT GmbH (DE) | 2001-10-24 | — | — | EP | claimed |
| CN-112029494-B | Perovskite nano material, composite luminescent material containing perovskite nano material, and preparation method and application of perovskite nano material | 致晶科技（北京）有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-113046796-A | Preparation method of nano double crystal layer and nano double crystal layer | 铂识科技股份有限公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-112055695-A | Nanoparticles for gene expression and uses thereof | 弗莱德哈钦森癌症研究中心 | 2020-12-08 | — | — | CN | disclosed |
| CN-110121336-A | Systems and methods for improving vaccine efficacy | 弗莱德哈钦森癌症研究中心 | 2019-08-13 | — | — | CN | disclosed |
| CN-109121413-A | Compositions and methods for programming therapeutic cells using targeted nucleic acid nanocarriers | 弗莱德哈钦森癌症研究中心 | 2019-01-01 | — | — | CN | disclosed |
| EP-2037325-B1 | ELECTROSTATIC IMAGE-DEVELOPING TONER | ZEON CORP (JP) | 2013-07-24 | — | — | EP | disclosed |
| EP-2037325-A1 | ELECTROSTATIC IMAGE-DEVELOPING TONER | ZEON CORPORATION (JP) | 2009-03-18 | — | — | EP | disclosed |
| CN-1589496-A | Optimal Application of Phase Change Materials in Cooling Devices | MERCK PATENT GMBH (DE) | 2005-03-02 | — | — | CN | disclosed |
| US-20050007740-A1 | Optimised application of pcms in chillers | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | US | disclosed |
| EP-1446833-A1 | OPTIMISED APPLICATION OF PCMS IN CHILLERS | MERCK PATENT GmbH (DE) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003093391-A1 | SURFACE MODIFICATION OF PHASE CHANGE MATERIALS | MERCK PATENT GMBH (DE) | 2003-11-13 | — | — | WO | disclosed |
| WO-2003046982-A1 | OPTIMISED APPLICATION OF PCMS IN CHILLERS | MERCK PATENT GMBH (DE) | 2003-06-05 | — | — | WO | disclosed |
| US-20020033247-A1 | Use of PCMs in heat sinks for electronic components | MERCK PATENT GMBH (DE) | 2002-03-21 | — | — | US | disclosed |
| US-20020016505-A1 | Heat storage material having solid/solid phase transition remains solid through application; heat resistance; materials handling | MERCK PATENT GMBH (DE) | 2002-02-07 | — | — | US | disclosed |
| EP-1162659-A2 | Use of PCM in heat sinks for electronic devices | MERCK PATENT GmbH (DE) | 2001-12-12 | — | — | EP | disclosed |
| EP-1148108-A1 | Storage media for latent heat storage units | MERCK PATENT GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| US-3976627-A | Vulcanizable compositions of carboxyl-containing polymers | THE B.F. GOODRICH COMPANY (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016505-A1 | Heat storage material having solid/solid phase transition remains solid through application; heat resistance; materials handling | HSPH1, HSP90AA1, HSPA1A | SIGMAR1 2815/4885TSHR 4373/4885ALDH1A1 1431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.