Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 11/20 | 0.69 |
| ▸ | LMNA | P02545 | 11/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.69 |
| ▸ | CCR6 | P51684 | 2/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459991 | 0.82 | KDM4E (0.70) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL9996591 | 0.81 | HIF1A (0.60) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL11090971 | 0.78 | KDM4E (0.65) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL11955258 | 0.78 | HTT (1.00) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL4249561 | 0.77 | KDM4E (0.64) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL15759426 | 0.76 | KDM4E (0.62) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL12905271 | 0.76 | HTT (0.69) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL11955272 | 0.76 | HTT (0.67) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL4059710 | 0.76 | LMNA (0.53) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 | |
| Chloroxine SCHEMBL4457237 | 0.75 | HTT (0.74) | HTTLMNASMN1; SMN2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | disclosed |