Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | HTT | P42858 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | CCR6 | P51684 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | MMP14 | P50281 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342982 | 0.87 | KDM4E (0.59) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL4249561 | 0.86 | KDM4E (0.64) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL15759426 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL11090971 | 0.85 | KDM4E (0.65) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL7254726 | 0.83 | HIF1A (0.78) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL4457239 | 0.82 | HTT (0.69) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL18389658 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL10086618 | 0.80 | HIF1A (0.60) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL9996591 | 0.79 | HIF1A (0.60) | KDM4EALDH1A1ALOX12LMNAHTT | |
| SCHEMBL9996252 | 0.78 | KDM4E (0.60) | KDM4EALDH1A1ALOX12LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170071951-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | claimed |
| WO-2015077057-A1 | METHIONINE AMINOPEPTIDASE INHIBITORS FOR TREATING INFECTIOUS DISEASES | TEXAS SOUTHERN UNIVERSITY (US) | 2015-05-28 | — | — | WO | claimed |
| US-20150141415-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-05-21 | — | — | US | claimed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| US-20170304288-A1 | Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170304288-A1 | Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170304288-A1 | Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170071951-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071940-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071951-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071940-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071948-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071948-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170071948-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | TEXAS SOUTHERN UNIVERSITY (US) | 2017-03-16 | — | — | US | disclosed |
| WO-2015077057-A1 | METHIONINE AMINOPEPTIDASE INHIBITORS FOR TREATING INFECTIOUS DISEASES | TEXAS SOUTHERN UNIVERSITY (US) | 2015-05-28 | — | — | WO | disclosed |
| WO-2015077057-A1 | METHIONINE AMINOPEPTIDASE INHIBITORS FOR TREATING INFECTIOUS DISEASES | TEXAS SOUTHERN UNIVERSITY (US) | 2015-05-28 | — | — | WO | disclosed |
| US-20150141415-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-05-21 | — | — | US | disclosed |
| US-20150141415-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-05-21 | — | — | US | disclosed |
| US-20150141415-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-05-21 | — | — | US | disclosed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141415-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, DNPEP, METAP2 | KDM4E 3013/4885ALDH1A1 640/4885ALOX12 2036/4885 |
| US-20170304288-A1 | Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, METAP2, DNPEP | KDM4E 2412/4885ALDH1A1 2370/4885ALOX12 1902/4885 |
| US-20170071948-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, DNPEP, METAP2 | KDM4E 2771/4885ALDH1A1 660/4885ALOX12 2170/4885 |
| US-20170071951-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, DNPEP, METAP2 | KDM4E 2771/4885ALDH1A1 660/4885ALOX12 2170/4885 |
| US-20170071940-A1 | Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases | METAP1, DNPEP, METAP2 | KDM4E 2771/4885ALDH1A1 660/4885ALOX12 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.