Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.46 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133327 | 0.92 | KMT2A (0.60) | KMT2ANR1H4EPHX2HDAC1NAMPT | |
| SCHEMBL14485285 | 0.89 | SYK (0.62) | KMT2AHDAC1NAMPTSYKMEN1 | |
| SCHEMBL23959162 | 0.87 | HDAC1 (0.61) | KMT2ANR1H4EPHX2HDAC1NAMPT | |
| SCHEMBL8983815 | 0.85 | KMT2A (0.50) | KMT2ASYKMEN1GAA | |
| SCHEMBL991841 | 0.84 | HDAC1 (0.64) | KMT2ANR1H4EPHX2HDAC1NAMPT | |
| SCHEMBL6288470 | 0.84 | SYK (0.57) | KMT2AHDAC1NAMPTSYKMEN1 | |
| SCHEMBL7428120 | 0.84 | HDAC1 (0.56) | KMT2AHDAC1NAMPTSYKMEN1 | |
| SCHEMBL3013545 | 0.84 | KMT2A (0.51) | KMT2ANR1H4EPHX2HDAC1NAMPT | |
| SCHEMBL7289218 | 0.84 | HDAC1 (0.56) | KMT2AHDAC1NAMPTSYKMEN1 | |
| SCHEMBL24890651 | 0.84 | KDM1A (0.52) | NR1H4EPHX2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156825-A1 | Fluorescent compounds that bind to histone deacetylase | MERCK SHARP & DOHME CORP. | 2009-06-18 | — | — | US | disclosed |
| US-20090156825-A1 | Fluorescent compounds that bind to histone deacetylase | MERCK SHARP & DOHME CORP. | 2009-06-18 | — | — | US | disclosed |
| US-20090156825-A1 | Fluorescent compounds that bind to histone deacetylase | MERCK SHARP & DOHME CORP. | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156825-A1 | Fluorescent compounds that bind to histone deacetylase | HDAC1, HDAC3, HDAC11 | KMT2A 145/4885NR1H4 1001/4885EPHX2 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.