Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | SDCBP | O00560 | 1/20 | 0.52 |
| ▸ | SDC2 | P34741 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133327 | 0.95 | KMT2A (0.60) | HDAC1NR1H4EPHX2KMT2ANAMPT | |
| SCHEMBL1691047 | 0.88 | HDAC1 (0.67) | HDAC1NR1H4EPHX2KMT2ANAMPT | |
| SCHEMBL4457324 | 0.87 | KMT2A (0.51) | HDAC1NR1H4EPHX2KMT2ANAMPT | |
| SCHEMBL3013545 | 0.87 | KMT2A (0.51) | HDAC1NR1H4EPHX2KMT2ANAMPT | |
| SCHEMBL5549803 | 0.87 | HDAC1 (0.60) | HDAC1NR1H4EPHX2NAMPT | |
| SCHEMBL2570189 | 0.87 | HDAC1 (0.63) | HDAC1NR1H4EPHX2NAMPTSDCBP | |
| Dimethylformamide SCHEMBL28335949 | 0.86 | NR1H4 (0.50) | HDAC1NR1H4EPHX2KMT2ANAMPT | |
| SCHEMBL3180689 | 0.86 | L3MBTL1 (0.61) | HDAC1NAMPTSDCBPSDC2L3MBTL1 | |
| SCHEMBL30736827 | 0.85 | HDAC1 (0.58) | HDAC1NR1H4EPHX2KMT2ANAMPT | |
| SCHEMBL24891652 | 0.85 | NAMPT (0.66) | HDAC1NR1H4EPHX2KMT2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-05-25 | — | — | US | disclosed |
| WO-2021216828-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | CDK9, CDK19, CRBN | HDAC1 1293/4885NR1H4 4110/4885EPHX2 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.