SCHEMBL133327

SCHEMBL133327

CC(C)(C)OC(=O)NCc1ccc(C(=O)O)cc1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.60
NR1H4 Q96RI1 5/20 0.59
EPHX2 P34913 3/20 0.59
NAMPT P43490 2/20 0.56
HDAC1 Q13547 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.53
MAPT P10636 1/20 0.51
GAA P10253 1/20 0.51
MMP8 P22894 1/20 0.50
CA1 P00915 2/20 0.48
CA2 P00918 1/20 0.48
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
CA14 Q9ULX7 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23959162 0.95 HDAC1 (0.61) KMT2ANR1H4EPHX2NAMPTHDAC1
SCHEMBL4457324 0.92 KMT2A (0.51) KMT2ANR1H4EPHX2NAMPTHDAC1
SCHEMBL3013545 0.92 KMT2A (0.51) KMT2ANR1H4EPHX2NAMPTHDAC1
Dimethylformamide SCHEMBL28335949 0.90 NR1H4 (0.50) KMT2ANR1H4EPHX2NAMPTHDAC1
SCHEMBL3180689 0.90 L3MBTL1 (0.61) NAMPTHDAC1L3MBTL1MAPTGAA
SCHEMBL24891652 0.89 NAMPT (0.66) KMT2ANR1H4EPHX2NAMPTHDAC1
SCHEMBL8203403 0.88 NAMPT (0.54) KMT2ANR1H4EPHX2NAMPTHDAC1
SCHEMBL2874913 0.88 NAMPT (0.54) KMT2ANR1H4EPHX2NAMPTHDAC1
SCHEMBL10165179 0.87 NAMPT (0.56) KMT2ANR1H4EPHX2NAMPTHDAC1
SCHEMBL8127981 0.87 EPHX2 (0.59) KMT2ANR1H4EPHX2NAMPTHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1064 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250144069-A1 BILOBALIDE DERIVATIVE COMPOUNDS FOR TREATING NEUROLOGICAL DISEASES AND CANCERS THE CHINESE UNIVERSITY OF HONG KONG (CN) 2025-05-08 US claimed
US-12630512-B2 Agents for differentiating stem cells and treating cancer MINERVA BIOTECHNOLOGIES CORPORATION (US) 2026-05-19 US disclosed
CN-122029157-A Bilobalide derivatives for the treatment of neurological diseases and cancers 香港中文大学 2026-05-12 CN disclosed
EP-4720044-A1 AROMATIC AMIDES AND CONJUGATES THEREOF AS BINDERS TO TEAD Beactica Therapeutics AB (SE) 2026-04-08 EP disclosed
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions EMORY UNIVERSITY (US) 2026-03-24 US disclosed
US-20260022122-A1 NOVEL COMPOUND FOR INHIBITING NAMPT, AND COMPOSITION INCLUDING SAME CHECKMATE THERAPEUTICS INC. (KR) 2026-01-22 US disclosed
US-20260007787-A1 RADIOPHARMACEUTICAL SMALL MOLECULE INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN FOR TARGETED THERAPY AND DIAGNOSTIC IMAGING OF DESMOPLASTIC TUMORS TRUSTEES OF TUFTS COLLEGE 2026-01-08 US disclosed
US-20260000781-A1 FC CONJUGATES INCLUDING AN INHIBITOR OF CD73 AND USES THEREOF CIDARA THERAPEUTICS INC (US) 2026-01-01 US disclosed
US-20260001904-A1 COMPOUNDS AND METHODS FOR LIQUID PHASE OLIGONUCLEOTIDE SYNTHESIS HONGENE BIOTECH CORP (US) 2026-01-01 US disclosed
EP-3966226-B1 MASP INHIBITORY COMPOUNDS AND USES THEREOF BAYER AG (DE) 2025-12-24 EP disclosed
EP-0386839-A2 Tetrahydroquinoline derivatives useful for neurodegenerative disorders MERCK SHARP & DOHME LTD. (GB) 1990-09-12 EP disclosed
US-4954512-A Anti-ulcer composition Okamoto, Shosuke (JP) 1990-09-04 US disclosed
WO-1990008128-A1 NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS BUNDGAARD HANS (DK) 1990-07-26 WO disclosed
US-4895842-A Phenylalanine derivative and proteinase inhibitor SHOSUKE OKAMOTO (JP) 1990-01-23 US disclosed
US-4873253-A Phenylalanine derivative and proteinase inhibitor Okamoto, Shosuke (JP) 1989-10-10 US disclosed
EP-0186817-B1 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1989-08-02 EP disclosed
EP-0317959-A2 Anti-ulcer composition Okamoto, Shosuke (JP) 1989-05-31 EP disclosed
EP-0284632-A1 Phenylalanine derivative and proteinase inhibitor Okamoto, Shosuke (JP) 1988-10-05 EP disclosed
EP-0217286-A1 Phenylalanine derivative and proteinase inhibitor Okamoto, Shosuke (JP) 1987-04-08 EP disclosed
EP-0186817-A1 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1986-07-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260007787-A1 RADIOPHARMACEUTICAL SMALL MOLECULE INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN FOR TARGETED THERAPY AND DIAGNOSTIC IMAGING OF DESMOPLASTIC TUMORS FIBP, FRS2, FGFR1 KMT2A 3715/4885NR1H4 367/4885EPHX2 2207/4885
US-20260001904-A1 COMPOUNDS AND METHODS FOR LIQUID PHASE OLIGONUCLEOTIDE SYNTHESIS POLR2H, POLR2E, NSUN2 KMT2A 2280/4885NR1H4 453/4885EPHX2 1757/4885
US-20250144069-A1 BILOBALIDE DERIVATIVE COMPOUNDS FOR TREATING NEUROLOGICAL DISEASES AND CANCERS BTD, BCHE, BRCA1 KMT2A 1707/4885NR1H4 2968/4885EPHX2 1019/4885
US-12630512-B2 Agents for differentiating stem cells and treating cancer MCL1, POU2F1, NES KMT2A 1674/4885NR1H4 438/4885EPHX2 1391/4885
US-20260000781-A1 FC CONJUGATES INCLUDING AN INHIBITOR OF CD73 AND USES THEREOF FCGR2A, FCGR1A, FCGR3B KMT2A 1971/4885NR1H4 1856/4885EPHX2 316/4885
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions SLC6A4, HTR4, HTR1A KMT2A 189/4885NR1H4 695/4885EPHX2 2116/4885
US-20260022122-A1 NOVEL COMPOUND FOR INHIBITING NAMPT, AND COMPOSITION INCLUDING SAME NAMPT, NAPRT, NNT KMT2A 1987/4885NR1H4 491/4885EPHX2 1762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.