Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.67 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.67 |
| ▸ | PIM1 | P11309 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.57 |
| ▸ | IDH1 | O75874 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453849 | 1.00 | SIRT2 (0.67) | SIRT2SIRT1PIM1ALDH1A1HTT | |
| SCHEMBL16223215 | 0.84 | ALDH1A1 (0.59) | SIRT2SIRT1PIM1ALDH1A1HTT | |
| SCHEMBL3454022 | 0.84 | ALDH1A1 (0.80) | SIRT2SIRT1PIM1ALDH1A1HTT | |
| SCHEMBL2542529 | 0.80 | PIM1 (1.00) | SIRT2SIRT1PIM1PKMKMT2A | |
| SCHEMBL2542527 | 0.80 | PIM1 (1.00) | SIRT2SIRT1PIM1PKMKMT2A | |
| SCHEMBL2542522 | 0.80 | PIM1 (1.00) | SIRT2SIRT1PIM1PKMKMT2A | |
| SCHEMBL15430003 | 0.77 | SIRT2 (0.65) | SIRT2SIRT1ALDH1A1HTTPKM | |
| SCHEMBL4903900 | 0.77 | ALDH1A1 (0.60) | SIRT2SIRT1ALDH1A1HTTPKM | |
| SCHEMBL4903894 | 0.77 | ALDH1A1 (0.60) | SIRT2SIRT1ALDH1A1HTTPKM | |
| SCHEMBL14870544 | 0.77 | ALDH1A1 (0.62) | ALDH1A1HTTPKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064486-A9 | INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS, AND METHODS FOR TREATING CANCER | MUSC FOUND FOR RES DEV (US) | 2009-07-16 | — | — | WO | disclosed |