Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.80 |
| ▸ | MAPT | P10636 | 10/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.80 |
| ▸ | MEN1 | O00255 | 7/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.80 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.80 |
| ▸ | PIM1 | P11309 | 1/20 | 0.70 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | APP | P05067 | 3/20 | 0.60 |
| ▸ | SNCA | P37840 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457487 | 0.84 | SIRT2 (0.67) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3453849 | 0.84 | SIRT2 (0.67) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2545538 | 0.82 | PIM1 (1.00) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2545539 | 0.82 | PIM1 (1.00) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2545540 | 0.82 | PIM1 (1.00) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL16223215 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14870544 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10201731 | 0.75 | MAPT (1.00) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4903900 | 0.73 | ALDH1A1 (0.60) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4903894 | 0.73 | ALDH1A1 (0.60) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217235-A2 | INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS, AND METHODS FOR TREATING CANCER | Musc Foundation for Research Development (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009064486-A9 | INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS, AND METHODS FOR TREATING CANCER | MUSC FOUND FOR RES DEV (US) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009064486-A2 | INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS, AND METHODS FOR TREATING CANCER | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2009-05-22 | — | — | WO | disclosed |