Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27719952 | 0.90 | KDM1A (0.36) | KDM1ARECQLMEN1KMT2ANR1I2 | |
| Hydrochloric Acid SCHEMBL4451446 | 0.80 | KDM1A (0.41) | KDM1ARECQLMEN1KMT2ANR1I2 | |
| Hydrochloric Acid SCHEMBL4457776 | 0.77 | KDM1A (0.39) | KDM1ARECQLMEN1KMT2ANR1I2 | |
| SCHEMBL4446578 | 0.76 | KDM1A (0.43) | KDM1ARECQLMEN1KMT2ANR1I2 | |
| Hydrochloric Acid SCHEMBL4454009 | 0.74 | AKR1C1 (0.39) | MEN1KMT2AALDH1A1TSHRAKR1C3 | |
| Hydrochloric Acid SCHEMBL4452408 | 0.70 | KDM1A (0.47) | KDM1ARECQLMEN1KMT2AALDH1A1 | |
| SCHEMBL7855199 | 0.66 | KDM1A (0.48) | KDM1ARECQLMEN1KMT2ANR1I2 | |
| SCHEMBL59713 | 0.66 | KDM1A (0.48) | KDM1ARECQLMEN1KMT2ANR1I2 | |
| SCHEMBL598599 | 0.65 | TSHR (0.50) | KDM1ARECQLMEN1KMT2ANR1I2 | |
| SCHEMBL5027068 | 0.65 | TSHR (0.50) | KDM1ARECQLMEN1KMT2ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101245084-B | Phosphine-substituted vinyl-containing metallocene catalyst, and preparation method and application thereof | PETROCHINA CO LTD | 2013-02-20 | — | — | CN | disclosed |
| US-7595413-B2 | Phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2009-09-29 | — | — | US | disclosed |
| EP-1958969-A1 | A phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | Petrochina Company Limited (CN) | 2008-08-20 | — | — | EP | disclosed |
| CN-101245084-A | Phosphine-substituted vinyl-containing metallocene catalyst, and preparation method and application thereof | PETROCHINA CO LTD (CN) | 2008-08-20 | — | — | CN | disclosed |
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PI4K2B, PI4K2A, CPNE4 | KDM1A 963/4885RECQL 3548/4885MEN1 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.