Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 19/20 | 0.53 |
| ▸ | ARG2 | P78540 | 9/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22524568 | 1.00 | ARG1 (0.53) | ARG1ARG2CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL21904645 | 1.00 | ARG1 (0.53) | ARG1ARG2CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL21902875 | 0.99 | ARG1 (0.52) | ARG1ARG2 | |
| SCHEMBL21906658 | 0.99 | ARG1 (0.52) | ARG1ARG2 | |
| SCHEMBL20331801 | 0.83 | ARG1 (0.44) | ARG1ARG2 | |
| SCHEMBL21902870 | 0.83 | CYP1A2 (0.39) | ARG1ARG2CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL21906656 | 0.83 | ARG1 (0.52) | ARG1ARG2 | |
| SCHEMBL10229362 | 0.83 | ARG1 (0.52) | ARG1ARG2 | |
| SCHEMBL17506629 | 0.82 | SMN1; SMN2 (0.37) | ARG1ARG2CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL4449212 | 0.80 | ARG1 (0.46) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034509-B1 | ARGINASE INHIBITORS AS THERAPEUTICS | MARS INC (US) | 2020-04-22 | — | — | EP | disclosed |
| WO-2012058065-A1 | BORONATES AS ARGINASE INHIBITORS | MARS INCORPORATED (US) | 2012-05-03 | — | — | WO | disclosed |