Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 5/20 | 0.39 |
| ▸ | PARL | Q9H300 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRND | Q07001 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6902727 | 0.90 | IDH1 (0.44) | IDH1HSD11B1ALDH1A1 | |
| SCHEMBL4452501 | 0.77 | FAAH (0.35) | BRD4CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL22771268 | 0.73 | HCAR2 (0.40) | IDH1RAB9AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4575028 | 0.71 | ALDH1A1 (0.41) | IDH1HSD11B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8475478 | 0.71 | IDH1 (0.51) | IDH1HSD11B1ALDH1A1MTOR | |
| SCHEMBL8475475 | 0.71 | IDH1 (0.51) | IDH1HSD11B1ALDH1A1MTOR | |
| SCHEMBL10308853 | 0.71 | IDH1 (0.48) | IDH1HSD11B1SMN1; SMN2 | |
| SCHEMBL4454824 | 0.69 | GRM2 (0.40) | BRD4CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4480093 | 0.68 | ELANE (0.38) | HSD11B1NPC1RAB9AALDH1A1MMP2 | |
| SCHEMBL4450103 | 0.68 | GAA (0.40) | HSD11B1NPC1RAB9AALDH1A1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137577-A1 | HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137577-A1 | HETEROCYCLIC COMPOUNDS | CYP2D6, ABCG2, CYP2B6 | IDH1 376/4885PARL 3604/4885BRD4 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.