Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.49 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794999 | 0.81 | DHFR (0.49) | DHFR | |
| SCHEMBL1790427 | 0.80 | ALDH1A1 (0.36) | DHFR | |
| SCHEMBL1792738 | 0.75 | IGF1R (0.53) | — | |
| SCHEMBL1791868 | 0.73 | NOTUM (0.52) | — | |
| SCHEMBL22277760 | 0.72 | DHFR (0.51) | DHFRP2RX3P2RX2 | |
| SCHEMBL4472365 | 0.72 | DHFR (0.39) | DHFR | |
| SCHEMBL22277341 | 0.71 | DHFR (0.50) | DHFRP2RX3P2RX2 | |
| SCHEMBL22277732 | 0.71 | DHFR (0.50) | DHFRP2RX3P2RX2 | |
| SCHEMBL4462541 | 0.71 | DHFR (0.43) | DHFR | |
| SCHEMBL4462978 | 0.71 | ALDH1A1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |