Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 13/20 | 0.86 |
| ▸ | PDE2A | O00408 | 10/20 | 0.86 |
| ▸ | TBXA2R | P21731 | 9/20 | 0.86 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | TSPO | P30536 | 1/20 | 0.77 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
| ▸ | PTGFR | P43088 | 1/20 | 0.77 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.77 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.77 |
| ▸ | PTGIR | P43119 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991121 | 0.92 | PTGDR (1.00) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| SCHEMBL4548354 | 0.92 | PTGDR (1.00) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| SCHEMBL6470520 | 0.91 | PTGDR (0.74) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| Laropiprant SCHEMBL991107 | 0.87 | PTGDR (1.00) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| Laropiprant SCHEMBL29612617 | 0.87 | PTGDR (1.00) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| Diastereomer 2 SCHEMBL1044552 | 0.87 | PTGDR (1.00) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| Diastereomer 2 SCHEMBL32668949 | 0.87 | PTGDR (1.00) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| SCHEMBL14472807 | 0.85 | PTGDR (0.85) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| SCHEMBL4456631 | 0.84 | PTGDR (0.61) | PTGDRPDE2ATBXA2RPDE4ATSPO | |
| SCHEMBL5429663 | 0.82 | PTGDR (1.00) | PTGDRPDE2ATBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054423-A1 | Niacin receptor agonists, compositions containing such compounds and methods of treatment | MERCK SHARP & DOHME CORP. | 2009-02-26 | — | — | US | disclosed |
| US-20080139604-A1 | Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions | MERCK SHARP & DOHME CORP. | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139604-A1 | Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions | LDLR, HCAR1, FFAR1 | PTGDR 201/4885PDE2A 1108/4885TBXA2R 37/4885 |
| US-20090054423-A1 | Niacin receptor agonists, compositions containing such compounds and methods of treatment | FFAR1, HCAR1, GPR119 | PTGDR 527/4885PDE2A 1281/4885TBXA2R 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.