Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462856 | 0.88 | PRMT5 (0.67) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL16994564 | 0.84 | KDM4E (0.68) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL17457122 | 0.84 | KDM4E (0.68) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL17457123 | 0.84 | KDM4E (0.68) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL4331124 | 0.83 | KDM4E (0.72) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL4457834 | 0.83 | MAPT (0.69) | MAPTKDM4EPOLBMAPK1LMNA | |
| SCHEMBL4453436 | 0.82 | HPGD (0.70) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL13954975 | 0.80 | PRMT5 (0.75) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL17457133 | 0.79 | MAPT (0.77) | KEAP1NFE2L2MAPTKDM4EPOLB | |
| SCHEMBL17457134 | 0.79 | MAPT (0.77) | KEAP1NFE2L2MAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |