Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455852 | 0.88 | HPGD (0.66) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4462856 | 0.87 | PRMT5 (0.67) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4459309 | 0.82 | KEAP1 (0.61) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4457834 | 0.81 | MAPT (0.69) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4332717 | 0.79 | MAPT (0.49) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4331124 | 0.78 | KDM4E (0.72) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL12417179 | 0.78 | MAPT (0.69) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4453439 | 0.78 | KMT2A (0.74) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL13887126 | 0.78 | KMT2A (0.74) | HPGDKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4326729 | 0.77 | MEN1 (1.00) | HPGDKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |