Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453467 | 0.88 | MAPT (0.65) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4459309 | 0.83 | KEAP1 (0.61) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4462856 | 0.81 | PRMT5 (0.67) | MAPTKDM4EMAPK1ALDH1A1POLB | |
| SCHEMBL4453436 | 0.81 | HPGD (0.70) | MAPTKDM4EMAPK1ALDH1A1POLB | |
| SCHEMBL4457842 | 0.77 | MAPT (0.67) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL13886802 | 0.77 | MAPT (0.67) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4324521 | 0.77 | MAPT (0.81) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4324519 | 0.77 | MAPT (0.81) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL13496999 | 0.75 | MAPT (0.70) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4453471 | 0.74 | ALDH1A1 (0.71) | MAPTKDM4ESMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |