Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.65 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693544 | 0.97 | MET (0.69) | METKDRAXLPDGFRA | |
| SCHEMBL372112 | 0.97 | MET (0.69) | METKDRAXLPDGFRA | |
| SCHEMBL29693546 | 0.89 | MET (0.60) | METKDRAXLPDGFRA | |
| SCHEMBL407686 | 0.89 | MET (0.60) | METKDRAXLPDGFRA | |
| SCHEMBL372064 | 0.89 | MET (0.69) | METKDRAXLPDGFRA | |
| SCHEMBL372095 | 0.88 | MET (0.68) | METKDR | |
| SCHEMBL371816 | 0.86 | MET (0.61) | METKDRAXL | |
| SCHEMBL371811 | 0.85 | MET (0.64) | METKDRAXL | |
| SCHEMBL20525545 | 0.84 | MET (0.53) | METKDRAXL | |
| SCHEMBL15266665 | 0.83 | MET (0.62) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |