Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525675 | 0.92 | POLB (0.58) | METPOLBKDRAXL | |
| SCHEMBL20525829 | 0.88 | MET (0.47) | METPOLBKDRAXL | |
| SCHEMBL29693544 | 0.87 | MET (0.69) | METKDRAXL | |
| SCHEMBL372112 | 0.87 | MET (0.69) | METKDRAXL | |
| SCHEMBL20525807 | 0.85 | MET (0.47) | METPOLBTHRBKDRTDP1 | |
| SCHEMBL20525633 | 0.84 | MET (0.52) | METPOLBKDRAXL | |
| SCHEMBL4459639 | 0.84 | MET (0.65) | METKDRAXL | |
| SCHEMBL20525748 | 0.83 | MET (0.49) | METALDH1A1KDR | |
| SCHEMBL20525804 | 0.82 | POLB (0.48) | METPOLBKDRAXL | |
| SCHEMBL20525610 | 0.82 | POLB (0.48) | METPOLBKDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |