Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.32 |
| ▸ | C1R | P00736 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813182 | 0.82 | BACE1 (0.38) | BACE1HCAR1MPL | |
| SCHEMBL1172224 | 0.76 | BACE1 (0.32) | BACE1 | |
| SCHEMBL1171905 | 0.74 | CTSD (0.40) | BACE1 | |
| SCHEMBL4458379 | 0.73 | CYP3A4 (0.35) | NPSR1 | |
| SCHEMBL1172152 | 0.73 | TAAR1 (0.39) | — | |
| SCHEMBL29974839 | 0.73 | HTT (0.31) | — | |
| SCHEMBL1171691 | 0.69 | BACE1 (0.41) | BACE1 | |
| SCHEMBL30157203 | 0.68 | JAK2 (0.31) | ALOX5APFEN1 | |
| SCHEMBL26922378 | 0.67 | BACE1 (0.33) | BACE1MPL | |
| SCHEMBL1171769 | 0.67 | ALDH1A1 (0.41) | POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |