Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428953 | 0.84 | AKR1B1 (0.55) | AKR1B1TSHRTDP1 | |
| SCHEMBL2548077 | 0.83 | AKR1B1 (0.51) | AKR1B1TSHRTDP1 | |
| SCHEMBL11334633 | 0.80 | AKR1B1 (0.60) | AKR1B1TSHRTDP1 | |
| SCHEMBL444596 | 0.79 | CASP6 (0.39) | AKR1B1 | |
| SCHEMBL11341929 | 0.79 | AKR1B1 (0.67) | AKR1B1TSHRTDP1 | |
| SCHEMBL9790142 | 0.77 | AKR1B1 (0.62) | AKR1B1TSHRTDP1 | |
| SCHEMBL9588316 | 0.77 | AKR1B1 (0.62) | AKR1B1TSHRTDP1 | |
| SCHEMBL9589456 | 0.77 | AKR1B1 (0.62) | AKR1B1TSHRTDP1 | |
| SCHEMBL449885 | 0.76 | BACE1 (0.38) | AKR1B1 | |
| SCHEMBL448629 | 0.73 | AKR1B1 (0.67) | AKR1B1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. | 2012-03-15 | — | — | US | disclosed |
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | APP, BACE1, PSEN1 | AKR1B1 112/4885TSHR 4602/4885TDP1 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.