Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | DRD4 | P21917 | 6/20 | 0.37 |
| ▸ | DRD3 | P35462 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465981 | 0.69 | NOTUM (0.49) | NOTUMDRD2DRD4DRD3MEN1 | |
| SCHEMBL7650321 | 0.67 | PRMT5 (0.53) | NOTUMDRD2DRD4DRD3MEN1 | |
| SCHEMBL4459340 | 0.66 | PTPN1 (0.43) | IGF1RDRD2DRD4DRD3 | |
| SCHEMBL4460763 | 0.66 | NOTUM (0.50) | NOTUMDRD2DRD4DRD3MEN1 | |
| SCHEMBL6767528 | 0.66 | DRD2 (0.69) | DRD2DRD4DRD3 | |
| SCHEMBL4459206 | 0.66 | PTPN1 (0.44) | IGF1RDRD2DRD4DRD3 | |
| SCHEMBL6767690 | 0.65 | DRD2 (0.74) | DRD2DRD4DRD3 | |
| SCHEMBL4307364 | 0.63 | NOTUM (0.56) | NOTUMDRD2DRD4DRD3MAPT | |
| SCHEMBL4665512 | 0.62 | PRMT5 (0.52) | NOTUMMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL12420831 | 0.61 | SMN1; SMN2 (0.53) | NOTUMDRD2DRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |