Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | DRD4 | P21917 | 7/20 | 0.41 |
| ▸ | DRD3 | P35462 | 7/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459206 | 0.99 | PTPN1 (0.44) | PTPN1IGF1RDRD2DRD4DRD3 | |
| SCHEMBL4467729 | 0.84 | IGF1R (0.42) | IGF1RLTA4H | |
| SCHEMBL4459152 | 0.82 | IGF1R (0.43) | IGF1R | |
| SCHEMBL4464502 | 0.81 | IGF1R (0.44) | IGF1R | |
| SCHEMBL4465981 | 0.77 | NOTUM (0.49) | DRD2DRD4DRD3 | |
| SCHEMBL4460763 | 0.70 | NOTUM (0.50) | DRD2DRD4DRD3 | |
| SCHEMBL4461468 | 0.68 | PTPN1 (0.47) | PTPN1IGF1RDRD2DRD4DRD3 | |
| SCHEMBL4466081 | 0.66 | DRD2 (0.41) | IGF1RDRD2DRD4DRD3 | |
| SCHEMBL4461287 | 0.66 | IGF1R (0.40) | IGF1RDRD2DRD4DRD3 | |
| SCHEMBL21121935 | 0.65 | CXCR1 (0.79) | PTPN1CXCR1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |