Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28300555 | 0.85 | KMT2A (0.51) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL2117365 | 0.80 | SMN1; SMN2 (0.47) | ALDH1A1MAPTSMN1; SMN2HTTKMT2A | |
| SCHEMBL519443 | 0.79 | MAPT (0.37) | ALDH1A1ALOX15GFERADAM17MAPT | |
| SCHEMBL4556627 | 0.78 | ALOX15 (0.38) | ALDH1A1ALOX15GFERADAM17MAPT | |
| SCHEMBL5480662 | 0.75 | RECQL (0.41) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL6305678 | 0.74 | ALDH1A1 (0.47) | ALDH1A1ALOX15GFERADAM17MAPT | |
| SCHEMBL1530165 | 0.73 | ESR1 (0.39) | ALDH1A1MAPTTSHRLMNAHTT | |
| SCHEMBL7034982 | 0.73 | KMT2A (0.47) | ALDH1A1ALOX15MAPTTSHRSMN1; SMN2 | |
| SCHEMBL2497436 | 0.73 | EPHX2 (0.44) | ALDH1A1LMNAHTT | |
| SCHEMBL2472803 | 0.72 | MEN1 (0.43) | ALDH1A1ALOX15MAPTTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144632-A1 | NOVEL COMPOUNDS | PFIZER LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |