Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.41 |
| ▸ | CNR2 | P34972 | 5/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461741 | 0.92 | P2RX7 (0.50) | P2RX7CNR2CRHR1KCNJ6KCNJ5 | |
| SCHEMBL4479948 | 0.89 | CNR2 (0.42) | P2RX7CNR2CRHR1KCNJ6KCNJ5 | |
| SCHEMBL2180874 | 0.86 | P2RX7 (0.57) | P2RX7CNR2CRHR1HDAC3HDAC4 | |
| SCHEMBL13472679 | 0.80 | P2RX7 (0.65) | P2RX7 | |
| SCHEMBL4461685 | 0.80 | P2RX7 (0.65) | P2RX7 | |
| SCHEMBL4462526 | 0.78 | P2RX7 (0.67) | P2RX7CNR2CRHR1HDAC3HDAC4 | |
| SCHEMBL4461796 | 0.78 | P2RX7 (0.47) | P2RX7CNR2 | |
| Hydrochloric Acid SCHEMBL4463402 | 0.78 | P2RX7 (0.68) | P2RX7CNR2CRHR1HDAC3HDAC4 | |
| SCHEMBL4480019 | 0.77 | P2RX7 (0.55) | P2RX7CNR2CRHR1 | |
| SCHEMBL2180488 | 0.77 | P2RX7 (0.50) | P2RX7CNR2CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1837330-B1 | Benzamide inhibitors of the P2X7 receptor | PFIZER PROD INC (US) | 2012-10-24 | — | — | EP | claimed |
| EP-1837330-A1 | Benzamide inhibitors of the P2X7 receptor | Pfizer Products Inc. (US) | 2007-09-26 | — | — | EP | claimed |
| US-20070142329-A1 | Benzamide Inhibitors of the P2X7 Receptor | PFIZER INC. | 2007-06-21 | — | — | US | claimed |
| EP-1837330-B1 | Benzamide inhibitors of the P2X7 receptor | PFIZER PROD INC (US) | 2012-10-24 | — | — | EP | disclosed |
| US-7553972-B2 | Benzamide inhibitors of the P2X7 receptor | PFIZER, INC. (US) | 2009-06-30 | — | — | US | disclosed |
| EP-1837330-A1 | Benzamide inhibitors of the P2X7 receptor | Pfizer Products Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20070142329-A1 | Benzamide Inhibitors of the P2X7 Receptor | PFIZER INC. | 2007-06-21 | — | — | US | disclosed |
| US-7186742-B2 | Benzamide inhibitors of the P2X7 receptor | PFIZER INC (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1626962-B1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PROD INC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20050009900-A1 | Benzamide inhibitors of the P2X7 receptor | ZOETIS LLC | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142329-A1 | Benzamide Inhibitors of the P2X7 Receptor | IL1R1, P2RY1, P2RX1 | P2RX7 7/4885CNR2 117/4885CRHR1 430/4885 |
| US-20050009900-A1 | Benzamide inhibitors of the P2X7 receptor | IL1R1, P2RY1, P2RX1 | P2RX7 7/4885CNR2 117/4885CRHR1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.