Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.56 |
| ▸ | CSF1R | P07333 | 8/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461950 | 0.92 | EGFR (0.59) | EGFRERBB2CSF1RAURKAINSR | |
| SCHEMBL1894145 | 0.87 | EGFR (0.76) | EGFRERBB2 | |
| SCHEMBL1900730 | 0.83 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL1894888 | 0.80 | EGFR (0.74) | EGFRERBB2 | |
| SCHEMBL2909935 | 0.76 | CSF1R (0.85) | CSF1R | |
| SCHEMBL2910769 | 0.76 | CSF1R (0.68) | EGFRCSF1RCLK1 | |
| SCHEMBL1896814 | 0.73 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL2912246 | 0.73 | KCNH2 (0.62) | EGFRCSF1R | |
| SCHEMBL2910987 | 0.72 | KCNH2 (0.74) | CSF1R | |
| SCHEMBL5106023 | 0.72 | EGFR (1.00) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151910-A2 | COMBINATION PRODUCT OF RECEPTOR TYROSINE KINASE INHIBITOR AND FATTY ACID SYNTHASE INHIBITOR FOR TREATING CANCER | WYETH (US) | 2009-12-17 | — | — | WO | disclosed |