Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15629800 | 0.83 | DRD2 (0.46) | HTR3ALSSDRD2 | |
| SCHEMBL10177690 | 0.83 | HTR2A (0.46) | HTR3ALSSESR1ESR2 | |
| SCHEMBL15627273 | 0.80 | CNR2 (0.42) | HTR3ALSSESR2DRD2 | |
| SCHEMBL10032835 | 0.78 | FFAR4 (0.47) | — | |
| SCHEMBL435619 | 0.77 | HTR3A (0.59) | HTR3ALSSESR1ESR2CYP3A4 | |
| SCHEMBL5389925 | 0.77 | HTR3A (0.47) | HTR3ALSSDRD2 | |
| SCHEMBL15611484 | 0.75 | ESR2 (0.41) | HTR3AESR1ESR2CYP3A4CYP2D6 | |
| SCHEMBL13346945 | 0.73 | HTR3A (0.47) | HTR3ALSSDRD2 | |
| SCHEMBL218475 | 0.72 | HTR3A (0.59) | HTR3ALSSCYP2C9DRD2 | |
| SCHEMBL8747330 | 0.72 | HTR3A (0.50) | HTR3AESR2CYP2C9DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2052251-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-29 | — | — | EP | claimed |
| WO-2008013556-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICAL N.V. (BE) | 2008-01-31 | — | — | WO | claimed |