Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461885 | 0.87 | CYP19A1 (0.59) | CYP19A1CYP11B2KCNA5KCNH2NPY5R | |
| SCHEMBL4461686 | 0.85 | CYP2A6 (0.46) | CYP19A1KCNA5CYP2A6ALDH1A1MAPT | |
| SCHEMBL4469599 | 0.85 | CYP19A1 (0.51) | CYP19A1CYP11B2KCNA5KCNH2NPY5R | |
| SCHEMBL4460426 | 0.82 | CYP19A1 (0.48) | CYP19A1CYP11B2KCNA5NPY5RVNN1 | |
| SCHEMBL4461908 | 0.81 | CYP19A1 (0.63) | CYP19A1CYP11B2KCNA5NPY5RCYP11B1 | |
| SCHEMBL4461911 | 0.80 | CYP19A1 (0.46) | CYP19A1CYP11B2KCNA5KCNH2VNN1 | |
| SCHEMBL4458988 | 0.80 | CYP2A6 (0.39) | CYP19A1KCNA5CYP2A6ALDH1A1MAPT | |
| SCHEMBL4468111 | 0.78 | PTGS2 (0.43) | CYP2A6CYP3A4CYP3A5ALDH1A1MAPT | |
| SCHEMBL4458274 | 0.78 | CYP19A1 (0.49) | CYP19A1CYP11B2KCNA5KCNH2NPY5R | |
| SCHEMBL4466454 | 0.77 | CYP19A1 (0.48) | CYP19A1CYP11B2KCNA5VNN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | claimed |
| EP-1981507-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-10-22 | — | — | EP | claimed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |
| US-20090030043-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | disclosed |
| EP-1981507-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | KCNJ2, KCNH2, KCNH3 | CYP19A1 4359/4885CYP11B2 1911/4885KCNA5 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.