Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 6/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 5/20 | 0.40 |
| ▸ | FPR1 | P21462 | 2/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032968 | 1.00 | HDAC8 (0.43) | HDAC8HDAC6PGRPLA2G7AR | |
| SCHEMBL3024408 | 0.88 | PGR (0.51) | HDAC8HDAC6PGRARDPP4 | |
| SCHEMBL3024923 | 0.86 | PGR (0.51) | HDAC8HDAC6PGRARDPP4 | |
| SCHEMBL4456538 | 0.86 | PGR (0.51) | HDAC8HDAC6PGRARDPP4 | |
| SCHEMBL12345103 | 0.84 | FPR1 (0.41) | HDAC8HDAC6FPR1FPR2 | |
| SCHEMBL3031987 | 0.83 | AR (0.43) | HDAC8HDAC6PGRARDPP4 | |
| SCHEMBL3029493 | 0.82 | PGR (0.48) | HDAC8HDAC6PGRARDPP4 | |
| SCHEMBL4453837 | 0.82 | PGR (0.48) | HDAC8HDAC6PGRARDPP4 | |
| SCHEMBL3028354 | 0.81 | HDAC8 (0.42) | HDAC8HDAC6PGRARDPP4 | |
| SCHEMBL3025089 | 0.81 | TNF (0.47) | HDAC8HDAC6PGRARDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049104-A2 | PYRROLIDINONE ANILINES AS PROGESTERONE RECEPTOR MODULATORS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008021796-A2 | PYRROLIDINONE ANILINES AS PROGESTERONE RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |