Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172152 | 0.76 | TAAR1 (0.39) | HTR5A | |
| SCHEMBL1172224 | 0.76 | BACE1 (0.32) | HTR5A | |
| SCHEMBL4456989 | 0.74 | ALDH1A1 (0.36) | — | |
| SCHEMBL30157203 | 0.74 | JAK2 (0.31) | HTR5A | |
| SCHEMBL1172351 | 0.72 | BACE1 (0.38) | — | |
| SCHEMBL4454878 | 0.72 | GAA (0.40) | — | |
| SCHEMBL4459737 | 0.70 | BACE1 (0.38) | — | |
| SCHEMBL1171691 | 0.69 | BACE1 (0.41) | — | |
| SCHEMBL29974839 | 0.68 | HTT (0.31) | — | |
| SCHEMBL1171769 | 0.67 | ALDH1A1 (0.41) | HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |