Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460584 | 0.88 | TAAR1 (0.44) | TAAR1KDM4CLRRK2GAAVNN1 | |
| SCHEMBL4472842 | 0.87 | TAAR1 (0.40) | TAAR1KDM4CLRRK2VNN1PTGS2 | |
| SCHEMBL4457212 | 0.85 | KCNA5 (0.42) | OXTRHTR6HCRTR1HCRTR2CYP19A1 | |
| SCHEMBL4461835 | 0.85 | CYP19A1 (0.40) | OXTRHTR6HCRTR1HCRTR2CYP19A1 | |
| SCHEMBL4461909 | 0.85 | TAAR1 (0.39) | TAAR1KDM4CLRRK2VNN1PTGS2 | |
| SCHEMBL4472149 | 0.84 | TAAR1 (0.41) | TAAR1LRRK2GAANAMPTPTGS2 | |
| SCHEMBL4457222 | 0.84 | TAAR1 (0.43) | TAAR1LRRK2GAANAMPTPTGS2 | |
| SCHEMBL4462676 | 0.83 | PTGS2 (0.41) | TAAR1KCNH2LRRK2PTGS2 | |
| SCHEMBL4458283 | 0.82 | KCNA5 (0.44) | TAAR1KCNH2KDM4CLRRK2PTGS2 | |
| SCHEMBL4457675 | 0.82 | KCNA5 (0.41) | OXTRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | disclosed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | KCNJ2, KCNH2, KCNH3 | OXTR 2684/4885HTR6 1435/4885CYP11B1 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.