SCHEMBL4463230

SCHEMBL4463230

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1I

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 4/20 0.80
ADORA1 P30542 2/20 0.80
PI4KA P42356 2/20 0.80
PI4K2B Q8TCG2 2/20 0.80
PI4K2A Q9BTU6 2/20 0.80
PI4KB Q9UBF8 2/20 0.80
DPP4 P27487 1/20 0.80
MEN1 O00255 1/20 0.80
SLC28A1 O00337 1/20 0.80
MAP3K7 O43318 1/20 0.80
SLC28A2 O43868 1/20 0.80
GAPDH P04406 1/20 0.80
MAPK1 P28482 1/20 0.80
ADORA2A P29274 1/20 0.80
ADORA2B P29275 1/20 0.80
STAT6 P42226 1/20 0.80
KMT2A Q03164 1/20 0.80
SMN1; SMN2 Q16637 1/20 0.80
DOT1L Q8TEK3 1/20 0.80
SLC29A1 Q99808 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16341965 1.00 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
SCHEMBL14853733 1.00 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
SCHEMBL15798533 1.00 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
SCHEMBL4463227 1.00 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
SCHEMBL14946319 1.00 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
SCHEMBL4463234 1.00 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
SCHEMBL31388262 1.00 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
Phosphoric Acid SCHEMBL21465129 0.94 ADORA3 (0.72) ADORA3ADORA1PI4KAPI4K2BPI4K2A
SCHEMBL2580936 0.91 ADORA3 (0.80) ADORA3ADORA1PI4KAPI4K2BPI4K2A
Adenosine SCHEMBL24538665 0.89 ADORA3 (1.00) ADORA3ADORA1PI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090198047-A1 2'-Modified Oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 2009-08-06 US disclosed
US-20080032945-A1 2'-MODIFIED OLIGONUCLEOTIDES ISIS PHARMACEUTICALS, INC. (US) 2008-02-07 US disclosed
US-7138517-B2 Sugar modified oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 2006-11-21 US disclosed
EP-0549615-B1 SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION ISIS PHARMACEUTICALS INC (US) 2006-02-22 EP disclosed
EP-1443051-A2 Sugar modified oligonucleotides that detect and modulate gene expression ISIS PHARMACEUTICALS, INC. (US) 2004-08-04 EP disclosed
EP-0604409-B1 OLIGONUCLEOTIDE ANALOGS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION ISIS PHARMACEUTICALS INC (US) 2004-07-14 EP disclosed
EP-1418179-A2 Compositions and methods for detecting and modulating rna activity and gene expression ISIS PHARMACEUTICALS, INC. (US) 2004-05-12 EP disclosed
US-20030187240-A1 2' -modified oligonucleotides ISIS PHARMACEUTICALS, INC. 2003-10-02 US disclosed
US-6531584-B1 Nuclease resistant oligonucleotide analogs; DNA or RNA modulation; diagnosis, thearpy of viral diseases ISIS PHARMACEUTICALS, INC. 2003-03-11 US disclosed
US-20030004325-A1 Sugar modified oligonucleotides ISIS PHARMACEUTICALS, INC. 2003-01-02 US disclosed
US-6005087-A NUCLEASE RESISTANT OLIGONUCLEOTIDES WHICH ARE USEFUL AS THERAPEUTICS, DIAGNOSTICS, AND RESEARCH REAGENTS FOR VARIOUS VIRAL DISEASES ISIS PHARMACEUTICALS, INC. (US) 1999-12-21 US disclosed
US-5872232-A 2'-O-modified oligonucleotides ISIS PHARMACEUTICALS INC. (US) 1999-02-16 US disclosed
US-5859221-A HYBRID DNA, RNA; NUCLEASE RESISTANT ISIS PHARMACEUTICALS, INC. (US) 1999-01-12 US disclosed
US-5670633-A TREATMENT AND DIAGNOSIS OF DISEASES AMENABLE TO MODULATION OF THE PRODUCTION OF SELECTED PROTEINS ISIS PHARMACEUTICALS, INC. (US) 1997-09-23 US disclosed
EP-0549615-A4 SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION ISIS PHARMACEUTICALS INC (US) 1997-08-27 EP disclosed
EP-0604409-A4 COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION. ISIS PHARMACEUTICALS INC (US) 1996-06-12 EP disclosed
EP-0604409-A1 COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1994-07-06 EP disclosed
EP-0549615-A1 SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1993-07-07 EP disclosed
WO-1992003568-A1 SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1992-03-05 WO disclosed
WO-1991010671-A1 COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1991-07-25 WO disclosed