Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 2/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12045659 | 0.83 | CYP1A2 (0.43) | CYP2C19CYP3A4MEN1MAPK1KMT2A | |
| SCHEMBL24723402 | 0.81 | HSD11B1 (0.33) | HSD11B1USP2CYP2C9CYP1A2SPR | |
| SCHEMBL26806776 | 0.81 | CYP2C9 (0.50) | CYP2C19CYP3A4MEN1MAPK1KMT2A | |
| SCHEMBL28170910 | 0.80 | CYP3A4 (0.34) | CYP2C19CYP3A4MEN1MAPK1KMT2A | |
| SCHEMBL18701743 | 0.78 | CYP3A4 (0.38) | CYP3A4HSD11B1MEN1MAPK1KMT2A | |
| SCHEMBL24341888 | 0.78 | MAPT (0.42) | HSD11B1MEN1KMT2AHSD17B10CYP2C9 | |
| SCHEMBL24597125 | 0.78 | ALDH1A1 (0.40) | CYP2C19CYP3A4MAPK1USP2HSD17B10 | |
| SCHEMBL22605402 | 0.78 | ALDH1A1 (0.46) | MEN1KMT2ACYP1A2TSHRALDH1A1 | |
| SCHEMBL23188165 | 0.78 | CYP1A2 (0.37) | HSD11B1CYP2C9CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL5748187 | 0.77 | CYP3A4 (0.36) | CYP2C19CYP3A4MEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889591-B2 | PDE9 inhibitor and use thereof | NANJING TRANSTHERA BIOSCIENCES CO. LTD. (CN) | 2021-01-12 | — | — | US | disclosed |
| US-20200115384-A1 | PDE9 INHIBITOR AND USE THEREOF | TRANSTHERA SCIENCES (NANJING), INC. (CN) | 2020-04-16 | — | — | US | disclosed |
| US-7504512-B2 | N-acylsulfonamide apoptosis promoters | ABBOTT LABORATORIES (US) | 2009-03-17 | — | — | US | disclosed |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | ABBVIE INC. | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10889591-B2 | PDE9 inhibitor and use thereof | PDE3A, PDE9A, PDE3B | CYP2C19 93/4885CYP3A4 376/4885HSD11B1 69/4885 |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | CYP2C19 4438/4885CYP3A4 3986/4885HSD11B1 2215/4885 |
| US-20200115384-A1 | PDE9 INHIBITOR AND USE THEREOF | PDE3A, PDE9A, PDE3B | CYP2C19 93/4885CYP3A4 376/4885HSD11B1 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.