Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171920 | 0.81 | SMN1; SMN2 (0.43) | ALDH1A1POLBLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL1171998 | 0.79 | CYP19A1 (0.35) | ALDH1A1KMT2AMEN1TP53MAPT | |
| SCHEMBL1171769 | 0.78 | ALDH1A1 (0.41) | ALDH1A1CYP3A4KMT2AMEN1POLB | |
| SCHEMBL1171716 | 0.72 | MAPT (0.37) | ALDH1A1CYP3A4ACHEKMT2AMEN1 | |
| SCHEMBL1171710 | 0.71 | HSP90AA1 (0.37) | POLBMAPTBACE1SMN1; SMN2 | |
| SCHEMBL4458379 | 0.70 | CYP3A4 (0.35) | CYP3A4SMN1; SMN2 | |
| SCHEMBL1171878 | 0.69 | ALDH1A1 (0.35) | ALDH1A1POLBMAPTSMN1; SMN2HPGD | |
| SCHEMBL12813223 | 0.66 | HTT (0.38) | ALDH1A1KMT2AMEN1BACE1KDM4E | |
| SCHEMBL4459737 | 0.64 | BACE1 (0.38) | POLBBACE1EPHX2 | |
| SCHEMBL11042537 | 0.62 | KMT2A (0.47) | ALDH1A1CYP3A4ACHEKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |