Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.58 |
| ▸ | TP53 | P04637 | 6/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.57 |
| ▸ | CHRNA5 | P30532 | 3/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 10/20 | 0.52 |
| ▸ | RAB9A | P51151 | 10/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463851 | 1.00 | SMN1; SMN2 (0.58) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1423487 | 0.86 | SMN1; SMN2 (0.77) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1422602 | 0.81 | NPC1 (0.77) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL8051460 | 0.76 | SMN1; SMN2 (0.77) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL3796996 | 0.75 | SMN1; SMN2 (1.00) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1422890 | 0.75 | CHRNB2 (1.00) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL12171589 | 0.75 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL5959951 | 0.74 | SMN1; SMN2 (0.84) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL4456725 | 0.73 | CA9 (0.55) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL4456727 | 0.73 | CA9 (0.55) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101763-A2 | PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE | Abbott Laboratories (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008073942-A2 | PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE | ABBOTT LABORATORIES (US) | 2008-06-19 | — | — | WO | disclosed |