Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | KRAS | P01116 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.53 |
| ▸ | P4HB | P07237 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464027 | 1.00 | ESR1 (0.62) | ESR1ESR2CYP1B1MCL1MAPT | |
| SCHEMBL1224370 | 0.84 | CYP1B1 (0.63) | ESR1ESR2CYP1B1MAPTCA1 | |
| SCHEMBL362071 | 0.84 | CYP1B1 (0.63) | ESR1ESR2CYP1B1MAPTCA1 | |
| SCHEMBL15502010 | 0.82 | CYP1B1 (0.69) | ESR1ESR2CYP1B1MAPTCA1 | |
| SCHEMBL498633 | 0.81 | ESR1 (0.62) | ESR1ESR2CYP1B1CA1CA2 | |
| SCHEMBL498634 | 0.81 | ESR1 (0.62) | ESR1ESR2CYP1B1CA1CA2 | |
| SCHEMBL1659832 | 0.79 | ESR1 (0.86) | ESR1ESR2CYP1B1MAPTCA1 | |
| SCHEMBL1659833 | 0.79 | ESR1 (0.86) | ESR1ESR2CYP1B1MAPTCA1 | |
| SCHEMBL22198827 | 0.79 | TNFRSF1A (0.83) | ESR1ESR2CYP1B1MAPTPTPN1 | |
| SCHEMBL31554987 | 0.79 | TNFRSF1A (0.83) | ESR1ESR2CYP1B1MAPTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701938-B1 | 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME | GENFIT (FR) | 2012-07-25 | — | — | EP | claimed |
| US-20080058412-A1 | 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same | GENFIT (FR) | 2008-03-06 | — | — | US | claimed |
| JP-2007517841-A | — | — | 2007-07-05 | — | — | JP | claimed |
| EP-1701938-A1 | 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME | Genfit (FR) | 2006-09-20 | — | — | EP | claimed |
| WO-2005073184-A1 | 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME | GENFIT (FR) | 2005-08-11 | — | — | WO | claimed |
| EP-1701938-B1 | 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME | GENFIT (FR) | 2012-07-25 | — | — | EP | disclosed |
| EP-1701938-B1 | 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME | GENFIT (FR) | 2012-07-25 | — | — | EP | disclosed |
| US-7547729-B2 | 1,3-diphenylprop-2-en-1-one derivative compounds, preparation method thereof and uses of same | GENFIT (FR) | 2009-06-16 | — | — | US | disclosed |
| US-7547729-B2 | 1,3-diphenylprop-2-en-1-one derivative compounds, preparation method thereof and uses of same | GENFIT (FR) | 2009-06-16 | — | — | US | disclosed |
| US-7547729-B2 | 1,3-diphenylprop-2-en-1-one derivative compounds, preparation method thereof and uses of same | GENFIT (FR) | 2009-06-16 | — | — | US | disclosed |
| US-20080058412-A1 | 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same | GENFIT (FR) | 2008-03-06 | — | — | US | disclosed |
| US-20080058412-A1 | 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same | GENFIT (FR) | 2008-03-06 | — | — | US | disclosed |
| US-20080058412-A1 | 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same | GENFIT (FR) | 2008-03-06 | — | — | US | disclosed |
| EP-1701938-A1 | 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME | Genfit (FR) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005073184-A1 | 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME | GENFIT (FR) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058412-A1 | 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same | TYR, DHPS, DDT | ESR1 2174/4885ESR2 1131/4885CYP1B1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.