Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LGMN | Q99538 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390496 | 0.83 | MAPT (0.53) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL390151 | 0.82 | MAPT (0.55) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL389367 | 0.81 | MAPT (0.59) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL386366 | 0.81 | MAPT (0.55) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL20522603 | 0.81 | MAPT (0.63) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL14018246 | 0.81 | MAPT (0.52) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL389027 | 0.81 | GPR119 (0.55) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL389195 | 0.81 | GPR119 (0.63) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL388740 | 0.80 | GPR119 (0.64) | MAPTTP53HTTCTSBALDH1A1 | |
| SCHEMBL6529147 | 0.76 | MAPT (0.68) | MAPTTP53HTTCTSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1808168-B1 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARM INC (US) | 2009-06-03 | — | — | EP | disclosed |