Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26621648 | 0.82 | BRD4 (0.43) | BRD4POLBSMN1; SMN2 | |
| SCHEMBL793001 | 0.77 | BRD4 (0.54) | BRD4SMN1; SMN2 | |
| SCHEMBL17294389 | 0.76 | BRD4 (0.49) | BRD4POLB | |
| SCHEMBL21026694 | 0.76 | BRD4 (0.49) | BRD4POLB | |
| SCHEMBL25595757 | 0.76 | CHRM4 (0.40) | CCNE1CDK2DPP4GSK3BSMN1; SMN2 | |
| SCHEMBL688823 | 0.76 | BRD4 (0.49) | BRD4POLBSMN1; SMN2 | |
| SCHEMBL18472043 | 0.76 | BRD4 (0.49) | BRD4POLB | |
| SCHEMBL14856811 | 0.76 | BRD4 (0.49) | BRD4POLBSMN1; SMN2 | |
| SCHEMBL27771663 | 0.76 | GBA1 (0.34) | CCNE1CDK2DPP4GSK3BSMN1; SMN2 | |
| SCHEMBL21872654 | 0.75 | BRD4 (0.47) | BRD4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049104-A2 | PYRROLIDINONE ANILINES AS PROGESTERONE RECEPTOR MODULATORS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008021796-A2 | PYRROLIDINONE ANILINES AS PROGESTERONE RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |