Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 8/20 | 0.55 |
| ▸ | CACNA2D1 | P54289 | 9/20 | 0.54 |
| ▸ | CACNB1 | Q02641 | 9/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 6/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.54 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460215 | 1.00 | CCR5 (0.55) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4460220 | 1.00 | CCR5 (0.55) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4460125 | 0.93 | CCR5 (0.58) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4473810 | 0.93 | CCR5 (0.58) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4460130 | 0.93 | CCR5 (0.58) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4467667 | 0.91 | CACNA2D1 (0.56) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4458722 | 0.91 | CACNA2D1 (0.56) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4458717 | 0.91 | CACNA2D1 (0.56) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4477780 | 0.89 | CACNA2D1 (0.57) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4475768 | 0.89 | CACNA2D1 (0.57) | CCR5CACNA2D1CACNB1CACNA1BCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507760-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-03-24 | — | — | US | claimed |
| JP-2007518742-A | — | — | 2007-07-12 | — | — | JP | claimed |
| EP-1718633-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-11-08 | — | — | EP | claimed |
| WO-2005070919-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-08-04 | — | — | WO | claimed |
| US-20050165065-A1 | N-type calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2005-07-28 | — | — | US | claimed |
| US-7507760-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-03-24 | — | — | US | disclosed |
| EP-1718633-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005070919-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-08-04 | — | — | WO | disclosed |
| US-20050165065-A1 | N-type calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165065-A1 | N-type calcium channel blockers | CACNA1B, CACNA1C, CACNA1D | CCR5 3482/4885CACNA2D1 40/4885CACNB1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.