Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.53 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889816 | 0.80 | KDM4E (0.52) | HSD11B1KCNN4PDE2APDE10ANPC1 | |
| SCHEMBL4559681 | 0.77 | MEN1 (0.44) | KCNN4NPC1ALDH1A1LMNARAB9A | |
| SCHEMBL4944318 | 0.74 | ALDH1A1 (0.46) | HSD11B1KCNN4PDE2APDE10ANPC1 | |
| SCHEMBL4349748 | 0.73 | ALDH1A1 (0.47) | HSD11B1KCNN4NPC1ALDH1A1LMNA | |
| SCHEMBL4350463 | 0.73 | ALDH1A1 (0.48) | KCNN4NPC1ALDH1A1LMNARAB9A | |
| SCHEMBL2747278 | 0.72 | HSD11B1 (0.74) | HSD11B1KCNN4CNR2PDE2APDE10A | |
| SCHEMBL4345607 | 0.71 | ALDH1A1 (0.76) | HSD11B1PDE2APDE10ANPC1ALDH1A1 | |
| SCHEMBL10012799 | 0.71 | HSD11B1 (0.46) | HSD11B1KCNN4PDE10ANPC1ALDH1A1 | |
| SCHEMBL8627702 | 0.71 | ALDH1A1 (0.46) | NPC1ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL7701143 | 0.71 | ALDH1A1 (0.50) | HSD11B1KCNN4CNR2ALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094205-A2 | 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2009-07-30 | — | — | WO | disclosed |