Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 18/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.72 |
| ▸ | PRKACA | P17612 | 8/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887921 | 0.85 | ROCK1 (0.71) | ROCK1CYP3A4PRKACAROCK2CIT | |
| SCHEMBL13887815 | 0.84 | ROCK1 (0.74) | ROCK1CYP3A4CITJAK2FLT3 | |
| SCHEMBL13887795 | 0.83 | ROCK1 (1.00) | ROCK1CYP3A4PRKACAROCK2CIT | |
| SCHEMBL4484666 | 0.83 | ROCK1 (1.00) | ROCK1CYP3A4CITJAK2FLT3 | |
| SCHEMBL27678745 | 0.83 | ROCK1 (0.61) | ROCK1CYP3A4PRKACAROCK2 | |
| SCHEMBL4593757 | 0.82 | ROCK1 (0.65) | ROCK1CYP3A4PRKACAROCK2JAK3 | |
| SCHEMBL4474000 | 0.81 | ROCK1 (0.60) | ROCK1CYP3A4PRKACAROCK2FLT3 | |
| SCHEMBL4482897 | 0.81 | ROCK1 (0.72) | ROCK1CYP3A4PRKACACITJAK2 | |
| SCHEMBL13887874 | 0.81 | ROCK1 (0.72) | ROCK1CYP3A4CITJAK2FLT3 | |
| SCHEMBL8939602 | 0.79 | ROCK1 (0.71) | ROCK1CYP3A4PRKACAROCK2CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514448-B2 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514448-B2 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514448-B2 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-07 | — | — | US | disclosed |
| EP-1756108-A2 | AZAINDOLES USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20060003968-A1 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2006-01-05 | — | — | US | disclosed |
| WO-2005103050-A2 | AZAINDOLES USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060003968-A1 | Azaindoles useful as inhibitors of rock and other protein kinases | ROCK2, ROCK1, TNK2 | ROCK1 2/4885CYP3A4 4258/4885PRKACA 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.