Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.65 |
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
| ▸ | PRKX | P51817 | 1/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27678745 | 0.82 | ROCK1 (0.61) | ROCK1CYP3A4CDC7ROCK2PRKACA | |
| SCHEMBL4465906 | 0.82 | ROCK1 (0.72) | ROCK1CYP3A4ROCK2PRKACAJAK3 | |
| SCHEMBL13887795 | 0.80 | ROCK1 (1.00) | ROCK1CYP3A4ROCK2PRKACACDK5 | |
| SCHEMBL13888118 | 0.79 | CYP3A4 (0.65) | ROCK1CYP3A4CDC7ROCK2PRKACA | |
| SCHEMBL13887691 | 0.79 | AKT1 (0.60) | ROCK1CYP3A4CDC7ROCK2PRKACA | |
| SCHEMBL4582789 | 0.78 | AKT1 (0.64) | ROCK1CYP3A4CDC7ROCK2CDK8 | |
| SCHEMBL13887959 | 0.78 | ROCK1 (0.76) | ROCK1CYP3A4CDK5DYRK1ACDK2 | |
| SCHEMBL8241818 | 0.76 | AKT1 (0.60) | ROCK1CYP3A4CDC7ROCK2CDK8 | |
| SCHEMBL8234027 | 0.76 | AKT1 (0.57) | ROCK1CYP3A4CDC7ROCK2PRKACA | |
| SCHEMBL4382843 | 0.75 | AKT1 (0.64) | ROCK1CYP3A4CDC7ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |