Sugi Predict

Sugi Predict / Compounds / SCHEMBL4466089

SCHEMBL4466089

SCHEMBL4466089

CCc1ccccc1Nc1sc(C(=O)c2cc(OC)ccc2OC)c(N)c1C#N

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 5/20 0.52
▸ MELK Q14680 4/20 0.48
▸ ALDH1A1 P00352 4/20 0.46
▸ POLB P06746 1/20 0.46
▸ MAPT P10636 9/20 0.45
▸ GAA P10253 1/20 0.45
▸ HPGD P15428 1/20 0.42
▸ MAPK1 P28482 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ MAPK8 P45983 1/20 0.42
▸ MAPK9 P45984 1/20 0.42
▸ MAPK10 P53779 1/20 0.42
▸ TP53 P04637 2/20 0.41
▸ LDHA P00338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4465938 0.93 LMNA (0.52) LMNAMELKALDH1A1POLBMAPT
SCHEMBL4470139 0.88 MELK (0.59) LMNAMELKALDH1A1POLBMAPT
SCHEMBL4487871 0.84 MAPT (0.55) LMNAMELKALDH1A1POLBMAPT
SCHEMBL4474619 0.83 ALDH1A1 (0.56) LMNAMELKALDH1A1POLBMAPT
SCHEMBL13633907 0.82 ALDH1A1 (0.54) LMNAMELKALDH1A1POLBMAPT
SCHEMBL4473035 0.81 MELK (0.59) LMNAMELKALDH1A1POLBMAPT
SCHEMBL2136772 0.80 MELK (0.52) LMNAMELKALDH1A1POLBMAPT
SCHEMBL4476854 0.78 MELK (0.49) LMNAMELKALDH1A1POLBMAPT
SCHEMBL4479525 0.77 LMNA (0.49) LMNAMELKALDH1A1POLBMAPT
SCHEMBL4504289 0.77 MELK (0.55) MELKALDH1A1POLBMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A LMNA 2349/4885MELK 3735/4885ALDH1A1 802/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A LMNA 2349/4885MELK 3735/4885ALDH1A1 802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.