Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.66 |
| ▸ | PDE5A | O76074 | 3/20 | 0.66 |
| ▸ | PDE1A | P54750 | 3/20 | 0.66 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.66 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.66 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133509 | 0.93 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133601 | 0.92 | YTHDC1 (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133797 | 0.89 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141261 | 0.89 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6862452 | 0.89 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133681 | 0.87 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141287 | 0.87 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133563 | 0.85 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3131818 | 0.85 | YTHDC1 (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3137729 | 0.85 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067607-A2 | COMBINATIONS OF PDE4 INHIBITORS AND ANTIPSYCHOTICS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-05-28 | — | — | WO | disclosed |