Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.55 |
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | PDE1A | P54750 | 2/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.55 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466950 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3137729 | 0.84 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133509 | 0.82 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133601 | 0.82 | YTHDC1 (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3131402 | 0.82 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141400 | 0.81 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133797 | 0.79 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141261 | 0.78 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6863830 | 0.78 | PDE5A (0.55) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141176 | 0.77 | YTHDC1 (0.55) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383767-A1 | TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2004-01-28 | — | — | EP | claimed |
| WO-2002098878-A1 | TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2002-12-12 | — | — | WO | claimed |