Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.72 |
| ▸ | HTT | P42858 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | TP53 | P04637 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | USP2 | O75604 | 3/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.72 |
| ▸ | LCK | P06239 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30153812 | 1.00 | KDM4E (0.72) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Hydrochloric Acid SCHEMBL16004700 | 0.98 | HSP90AA1 (0.70) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Iodoquinol SCHEMBL3460 | 0.84 | KDM4E (1.00) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Iodoquinol SCHEMBL29606817 | 0.84 | KDM4E (1.00) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Iodoquinol SCHEMBL29367180 | 0.84 | KDM4E (1.00) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Iodoquinol SCHEMBL28536045 | 0.82 | KDM4E (0.96) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Iodoquinol SCHEMBL28519246 | 0.82 | KDM4E (0.96) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Iodoquinol SCHEMBL2532141 | 0.82 | KDM4E (0.96) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| Iodoquinol SCHEMBL28518289 | 0.82 | KDM4E (0.96) | KDM4EMEN1KMT2AHSP90AA1HTT | |
| SCHEMBL112466 | 0.79 | KDM4E (0.76) | KDM4EMEN1KMT2AHSP90AA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| US-20150025044-A1 | IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION | THE JOHNS HOPKINS UNIVERSITY | 2015-01-22 | — | — | US | disclosed |
| US-20150025044-A1 | IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION | THE JOHNS HOPKINS UNIVERSITY | 2015-01-22 | — | — | US | disclosed |
| US-8828976-B2 | Identification and use of compounds that affect the fidelity of eukaryotic translation initiation codon selection | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-09 | — | — | US | disclosed |
| US-8828976-B2 | Identification and use of compounds that affect the fidelity of eukaryotic translation initiation codon selection | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-09 | — | — | US | disclosed |
| US-20110230451-A1 | IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-09-22 | — | — | US | disclosed |
| US-20110230451-A1 | IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-09-22 | — | — | US | disclosed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230451-A1 | IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION | EEF2K, RIOX2, EIF5B | KDM4E 2950/4885MEN1 2783/4885KMT2A 3392/4885 |
| US-20150025044-A1 | IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION | EEF2K, RIOX2, EIF5B | KDM4E 2950/4885MEN1 2783/4885KMT2A 3392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.