Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.41 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4468720 | 0.85 | LMNA (0.48) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4461917 | 0.85 | ALDH1A1 (0.58) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4458856 | 0.83 | KDM4E (0.52) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4456441 | 0.83 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4470646 | 0.82 | KDM4E (0.53) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4458598 | 0.82 | KDM4E (0.53) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4458008 | 0.82 | ALDH1A1 (0.53) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4470211 | 0.81 | LMNA (0.56) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4467697 | 0.81 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4467704 | 0.81 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | disclosed |