Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.40 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462384 | 0.90 | IGF1R (0.40) | IGF1RSLC5A7EPHX2 | |
| SCHEMBL4471687 | 0.86 | IGF1R (0.38) | IGF1R | |
| SCHEMBL4472354 | 0.85 | IGF1R (0.36) | IGF1R | |
| SCHEMBL4458966 | 0.84 | IGF1R (0.44) | IGF1REPHX2 | |
| SCHEMBL4466081 | 0.81 | DRD2 (0.41) | IGF1REPHX2 | |
| SCHEMBL4469451 | 0.80 | EPHX2 (0.33) | IGF1REPHX2 | |
| SCHEMBL4469489 | 0.76 | IGF1R (0.38) | IGF1R | |
| SCHEMBL4460700 | 0.75 | IGF1R (0.36) | IGF1R | |
| SCHEMBL4462239 | 0.74 | IGF1R (0.44) | IGF1RSLC5A7 | |
| SCHEMBL4459152 | 0.74 | IGF1R (0.43) | IGF1RSLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |